The New York Yankees and Houston Astros are both popular picks to face each other in the playoffs later this year, as both teams currently hold double-digit leads in their respective American League divisions. They are getting set to open a four-game series on Thursday night, with New York looking to extend its MLB-best record. The Yankees are on a 14-game home winning streak, opening a 12-game lead over Toronto in the AL East.

New York can match its longest home winning streak since 1961 with a win on Thursday night. The Yankees are -130 favorites in the latest MLB odds at Caesars Sportsbook, while the Astros are +110 underdogs. Before you make your MLB picks or parlays, be sure to check out the MLB predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a strong start to the 2022 season. It's on a 56-47 roll on top-rated MLB money-line picks through 11 weeks. Anybody who has followed it has seen profitable returns.

Now, the model has locked in three confident MLB best bets for Thursday. They all involve games at 7:05 p.m. ET or later, so there's still time to get these MLB picks in. If you successfully parlay the picks, you'd be looking at a payout of more than 5-1. You can see the model's MLB picks for Thursday only at SportsLine. 

Top MLB picks today

After simulating every game 10,000 times, one pick the model likes for Thursday is Chicago to beat Baltimore as a -160 favorite at 8:10 p.m. ET (see tickets at StubHub). The White Sox tend to take care of business against Baltimore, winning five straight home games in the head-to-head series. They have also won six of their last nine games this season, including two out of three against Toronto earlier this week.

Baltimore has lost eight straight games to Chicago overall, so its struggles against the White Sox have not only been on the road. Orioles' pitcher Dean Kremer is making just his fourth start of the season, while the White Sox have veteran Johnny Cueto on the mound. This will be Kremer's first-ever start against Chicago's hard-hitting lineup, which is one reason why the model loves the White Sox in this game.

Featured Game| Chicago White Sox vs. Baltimore Orioles

How to make MLB picks and parlays for Thursday

The model also locked in two other best bets for Thursday, including a selection on an underdog. You can only see the model's MLB parlay picks and best bets for Thursday at SportsLine

What MLB picks should you target for a payout of more than 5-1? And what underdog is the model backing on Thursday? Visit SportsLine now to see the MLB best bets for Thursday from a model that has a 56-47 record on top-rated MLB money-line picks through 11 weeks, and find out.