As we approach the halfway mark of the 2022 MLB season, the New York Yankees and the Houston Astros have pretty clearly established themselves as the two most dominant teams in the American League. The Yankees are 51-18 and have a 12-game lead in the AL East, while the Astros are 43-25 and own a 10-game cushion in the AL West. Now the powerhouses will go head-to-head in a four-game series at Yankee Stadium that begins on Thursday.

The first pitch is set for 7:05 p.m. ET. New York is the -125 money-line favorite (risk $125 to win $100) in the latest Yankees vs. Astros odds from Caesars Sportsbook, while Houston is a +105 underdog. The over-under for total runs scored is eight. Before making any Astros vs. Yankees picks, you need to see the MLB predictions and betting advice from SportsLine's advanced computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a strong start to the 2022 season. It's on a 56-47 roll on top-rated MLB money-line picks through 11 weeks. Anybody who has followed it has seen profitable returns.

Now, the model has set its sights on Yankees vs. Astros, and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model's picks. Here are several MLB odds and betting lines for Astros vs. Yankees:

  • Yankees vs. Astros moneyline: New York -125, Astros +105
  • Yankees vs. Astros run line: New York -1.5 (+150)
  • Yankees vs. Astros over-under: 8 runs
  • Yankees vs. Astros tickets: See tickets at StubHub
  • NYY: The total has gone over in four of the last five games the Yankees have played as a favorite
  • HOU: The Astros are 8-2 SU in their last 10 road games.
Featured Game| New York Yankees vs. Houston Astros

Why you should back the Astros

The model knows that Houston is a runaway leader in the AL West, holding a 10-game lead over the Rangers entering Thursday's action. Yordan Alvarez is establishing himself as one of the league's best hitters and enters this four-game series with 21 home runs, 51 RBIs and a staggering 1.064 OPS.

Houston will send lefty Framber Valdez to the mound on Thursday and the 28-year-old is having another impressive season, as he enters the game with a 7-3 record, a 2.78 ERA and 68 strikeouts over 81 innings. Current Yankees hitters have hit .199 in their careers against Valdez with a .304 slugging percentage.

Why you should back the Yankees

The Yankees have won 17 of their last 20 games entering Thursday's action and it's been an absolutely masterful season for Aaron Boone's squad. The Yankees lead the American League in both runs scored (353) and team ERA (2.90) and they are getting productivity from just about everywhere they could hope at this point.

There are six hitters in the Yankees lineup with an OPS+ that is better than league average, all five of the starting pitchers have an ERA of 3.27 or less, and Clay Holmes and Michael King are having dominant seasons out of the bullpen to help make up for the fact that Aroldis Chapman, Jonathan Loaisiga and Chad Green are all on the injured list. The team has a staggering +143 run differential and it's hard to bet against them until we see some sort of prolonged regression.

How to make Yankees vs. Astros picks

SportsLine's model is leaning over on the total, projecting 8.7 combined runs. It also says one side of the money line has all the value. You can only get the model's MLB picks at SportsLine.

So who wins Astros vs. Yankees? And which side has all the value? Visit SportsLine now to see which side you need to jump on, all from the model that has crushed its MLB picks, and find out.